High School Affiliated To Nanjing Normal University is a public high school directly under the Education Department of Jiangsu Province, a key high school of Jiangsu Province, a model school of Jiangsu Province, and a member of ISC. It is also one of the first national demonstration high schools. In the 1960s, it was listed as one of the three pilot schools of education reform in China by the Ministry of Education. Since the establishment of the school, the school is famous for "careful recruitment of good teachers, keen experiment, honest school spirit, nurturing good talent".

In history, High School Affiliated To Nanjing Normal University took the lead in carrying out experiments of Dalton system and "6-3-3" academic system reform in China, which established its position in the history of basic education in modern China. After the reform and opening up, the school conducted experiments on elective courses, extra-curricular activities, compulsory courses at different levels, and established a personalized, diversified and optional curriculum structure, which provided a preliminary experimental basis for the determination of new curriculum in national senior high schools. It provides examples for curriculum construction and management in the context of international exchange and International Baccalaureate curriculum, information curriculum system and high school diversified curriculum.

In November 2019, Dr. Robert Smiley, the CIO and Director of International Education Program of the School District of Janesville, Wisconsin, USA, visited High School Affiliated To Nanjing Normal University.